A total of 8 genes (RHEB, HSP90AB1, ATIC, HDAC1, MLST8, SQSTM1, SPNS1, and HSPB8) were observed to be significantly associated with the OS by multivariate cox regression analysis (Table 2), based on which we constructed autophagy prognostic signature to better predict the clinical outcomes (OS) for HCC patients. This evidence concerns the gene SPNS1 and hepatocellular carcinoma.