The knockdown of RHEB, a key regulator in mTOR signaling pathway [23], was related with an inhibited effect on the growth of SMMC-7721 cells, and the upregulated expression of RHEB in human HCC tissues was correlated poorer prognosis as compared with those who had lower expression level of RHB [24–29]. Here, RHEB is linked to hepatocellular carcinoma.