Hence, we aimed to study prevalence of SCH, in infertile females, explore associa-tion of PDE8B rs4704397 A/G and rs6885099 G/A polymorphisms with infertility in females suffering fromSCH and genotype-phenotype correlation of the polymorphisms with thyroid stimulating hormone (TSH) levelsin Gujarat population. This evidence concerns the gene PDE8B and spindle cell hemangioma.