Of note, serum sCD163 levels are significantly increased in patients with sJIA associated with MAS-HLH in comparison to patients with an active disease without MAS-HLH, in particular at disease onset, follow the clinical course in response to treatment and, of note, correlate with other surrogate biomarkers of systemic inflammatory burden, like sCD125 and ferritin [89]. This evidence concerns the gene CD163 and systemic-onset juvenile idiopathic arthritis.