Moreover, a recent study demonstrated that systemic lupus erythematosus patients with MAS-HLH display significantly higher levels of sCD163 in comparison with patients with other severe disease manifestations like lupus nephritis, autoimmune haemolytic anaemia or immune thrombocytopenia, with sCD163 levels correlating with disease activity [91]. This evidence concerns the gene CD163 and autoimmune hemolytic anemia.