Though not statistically significant, we noted a trend towards slightly higher P/M ratios in EIF3B-overexpressing cells compared with vector-transduced Prdm10F/F controls, suggestive of translation rates above baseline and consistent with previous reports that overexpression of the EIF3B subunit is sufficient to elevate levels of the entire eIF3 complex, thereby activating protein synthesis in cancer cell lines27. Here, EIF3A is linked to cancer.