Potential mutations that could affect cell metabolism and tumor microenvironment occur in phosphoglycerate dehydrogenase (PHGDH)9, cystathionine gamma-lyase (CTH)9, and sodium-hydrogen exchanger 1 (NHE-1) on 1p10, and capicua transcriptional repressor (CIC) on 19q11. The gene discussed is CTH; the disease is neoplasm.