LIPA and metabolic dysfunction-associated steatohepatitis: Despite the high adaptability of hepatocytes to attenuate cholesterol-induced organelle stress by coordinately regulating cholesterol esterification, efflux and catabolic pathways, impaired lysosomal function, reduced lysosomal acid lipase activity and cholesterol lipotoxicity have been reported in chronic human NASH livers, which was suggested to contribute to NASH pathogenesis42,50,51.