Moreover, nebivolol significantly inhibited the expression of the angiogenic markers IB4 (Fig. 8h), CD31 (Fig. 8i), Laminin (Fig. 8j), αSMA (Fig. 8k), and VEGFR2 (Fig. 8l) in breast carcinomas, further supporting a relevant role for β-adrenergic signaling in favoring tumor angiogenesis. This evidence concerns the gene ACTA1 and neoplasm.