However, ERBB2 amplification was often observed as arm-level events or separate from pter-located GISTIC peaks, including ASPSCR1 and RNF213 (Supplementary Fig. 5B), which is in stark contrast to the minimal amplification of ERBB2 observed in human breast cancers (Supplementary Fig. 5B, inlet). This evidence concerns the gene RNF213 and breast carcinoma.