AR and prostate cancer: To test whether rs72725854 and its linked SNP rs114798100 (r2 = 0.8)13 has any functional roles, we investigated the presence of androgen receptor (AR) binding using publicly available ChIP-seq data in the prostate cancer cell line LNCaP since, AR modulates gene expression in prostate tumors by binding with distal regulatory elements marked by H3K27ac, H3K4me1, and RNA polymerase II21.