ITGAX and lobular neoplasia: Recently, our study on the immunological characteristics of urinary cells in patients with LN showed that CD11c+ macrophages were abundantly present in the urine as well as the tubulointerstitium; moreover, urinary CD11c+ macrophages were immunologically active, expressed proinflammatory cytokines, and interacted with tubular epithelial cells, indicating their possible pathologic role in LN [12].