We found that serum levels of S100A8/A9 were significantly correlated with ILD structural damage (HRCT score) (r = 0.1642, p = 0.0157) and pulmonary function impairment (DLCO%: r = − 0.2066, p = 0.0061, FVC%: r = − 0.2156, p = 0.0050). The gene discussed is S100A8; the disease is interstitial lung disease.