BRD4 and diffuse intrinsic pontine glioma: However, due to the multitude of activated pathways, and regardless of the epigenetic or therapy-induced mechanism of upregulation of these RTKs, transcription regulators or invasiveness mediators, we believe that more general strategies, either immune or epigenetic, aiming shutdown of aberrant transcriptional programs, such as use of BRD4 inhibitors [90] (Fig. 5c-d), might prove beneficial in DIPG.