AKT1 and periodontitis: The present results not only indicated that the miR-181b-5p/PTEN/AKT signaling pathway functions as a potentially novel mechanism for physiological mechanical force contributing to periodontal homeostasis through the intercellular communication of exosomes in periodontal tissue, but also suggested the potential role of exosomes induced by mechanical force as therapeutic tools for periodontitis and periodontal regeneration.