The ECS is important in the control and regulation of body weight, since stimulation of CB1 (cannabinoid receptor 1) by anandamide (AEA) and 2-arachidonoylglyceride (2-AG) is associated with increased appetite, higher food intakes, weight gain, and obesity [8]. The gene discussed is CNR1; the disease is obesity due to melanocortin 4 receptor deficiency.