NFKB1 and schizophrenia: Despite this ambiguity, we do know that neurons have minimal basal or inducible NF-κB [46], that reactive astrocytes are found in both Shn2 KO mice and high neuroinflammation schizophrenia [23, 24, 47], and that NF-κB is essential in the adoption of a pro-inflammatory phenotype in astrocytes [48, 49].