Although individuals classified as having high cortical inflammation in both diagnostic groups showed widespread increases in NF-κB-related mRNAs, almost all (8 of 9 mRNAs) of the differences between the two inflamed groups were found in canonical NF-κB transcripts (TLR4, IKKβ, IκBα, IκBβ, IκBε, RelA, cRel, and NFKB1), which were decreased in high neuroinflammation schizophrenia compared to high neuroinflammation controls. This evidence concerns the gene IKBKB and schizophrenia.