Despite the shortcomings of this model system, the inclusion of an endogenous Nlrp3 allele was likely a critical factor in our discovery of an expanding neuroinflammatory phenotype resulting from expression of the Nlrp3L351P allele of neurons, a finding of importance as we work to understand the earliest stages of neuroinflammation in neurodegenerative disease. The gene discussed is NLRP3; the disease is neurodegenerative disease.