Among the 12 functional genes which were associated with the prognosis of COAD, high expression of TPM2, STMN2, CHMP4C, DUSP14, and GRIA3 had poorer survival rates, while low expression of WDR1, CPT2, KDM1A, NFE2L1, TBL3, TGFBR3, and FGFR2 had worse survival rates. The gene discussed is CHMP4C; the disease is colon adenocarcinoma.