It is worth pointing out that Narayanan S.P. et al. found that KDM1A plays a role in cell proliferation through regulating the E2F1 signaling pathway in oral cancer [70] and CBX8 interaction with HOXA9 was found to play an important role in MLL-AF9-Induced Leukemogenesis [71], which suggested that they may also play important roles in COAD. This evidence concerns the gene E2F1 and lip and oral cavity carcinoma.