Specifically, CyclinD1 (CCND1) polymorphisms were associated with CRC [30]; WNT2, a member of the WNT gene family, is involving in a signaling pathway which can promote colorectal cancer progression [31]; MET (MET Proto-Oncogene) may act as prognosis biomarkers for CRC [32]; HDAC2 (Histone Deacetylase 2) was found to be a potential target in CRC [33]. The gene discussed is HDAC2; the disease is colorectal cancer.