Therefore, the identified novel variants c.1118 T > C belongs to the Class I G6PD. This data provides evidence that this novel G6PD variant is a cause of nonspherocytic hemolytic anemia, and has significant clinical impact on the pathology of G6PD-D although the frequency of the variant is low in this cohort. Here, G6PD is linked to anemia, nonspherocytic hemolytic.