The total effect of rs2920656 on AKI-SP2 was βtotal = − 0.16 per allele (95% CI -0.24, − 0.10, p = 1.0 × 10− 4), which suggests that for each minor allele (T allele) of the genetic variant the risk of developing AKI-SP2 decreases by 16%. Here, SP2 is linked to acute kidney injury.