When combined with carcinoembryonic antigen-targeted T cell bispecific antibody (CEA-TCB), FAP-4-1BBL led to improved CD8+ T cell infiltration and tumor regression as compared to treatment with CEA-TCB alone in a murine model of gastric cancer (MKN45 cells xenografted with NIH/3T3-huFAP fibroblasts) [86]. Here, CEACAM5 is linked to neoplasm.