In a study of relapsed or refractory Hodgkin’s lymphoma patients who did not benefit from prior PD-1 blockade monotherapy, a combination of PD-1 inhibitors (nivolumab or pembrolizumab) with chemotherapy (in different combinations of vinblastine, gemcitabine, bendamustine, liposomal doxorubicin, ifosfamide, carboplatin, etoposide, cisplatin, cytarabine, dexamethasone, vinorelbine) resulted in an overall response rate (ORR) of 86%; while chemotherapy alone resulted in an ORR of 59% [30]. Here, PDCD1 is linked to Hodgkins lymphoma.