A more recent study quantifying plasma p-tau (T181) showed that the plasma p-tau (T181) in the AD group was significantly higher than that in the age-matched control group, but showed a too low cut-off value (0.0921 pg/mL) of plasma p-tau181 [20] This result with plasma p-tau (T181) differs from our ELISA results that serum p-tau (T181) did not differ between AMC, MCI, and Mild-AD. The gene discussed is MAPT; the disease is Alzheimer disease.