MAPT and Alzheimer disease: Serum t-tau elevation above 234.4 pg/mL distinguished Mild-AD from AMC group subjects with 75% sensitivity and 61.54% specificity (area under the curve (AUC) = 0.675, p = 0.044, Figure 1G), while serum p-tau (S202) above 58.34 pg/mL distinguished Mild-AD from AMC subjects with 78.95% sensitivity and but only 40% specificity (AUC = 0.5958, p = 0.281, Figure 1H).