In a murine experimental model of asthma, a positive correlation between P2X4R levels and inflammation severity has been found; blockage of P2X4R activation reversed some asthma remodeling hallmarks, including bronchoalveolar lavage fluid eosinophilia, peri-bronchial inflammation, Th2 cytokine production, and bronchial hyper-responsiveness [173,175]. This evidence concerns the gene P2RX4 and asthma.