C9orf72 and amyotrophic lateral sclerosis: An experiment was designed to silence C9orf72 employing miR-101 and miR-451 scaffolds (miC); consequently, two miC candidates were incorporated in a AAV5 vector in HEK293T cells and induced pluripotent stem cell (iPSC)-derived neurons, resulting in the silencing of C9orf72 which could help to alleviate the gain of toxicity described in ALS [104].