APP and Alzheimer disease: Overexpression of miR-31 in the hippocampus of AD triple-transgenic mice after stereotaxic injection of lentiviral particles encoding the primary miRNA, reduced APP, and BACE1 protein expression, where the latter promotes sequential processing of the former, resulting in accumulation of Aβ, recovery of cognitive functions, improved memory, decreased anxiety levels and reduced intraneuronal Aβ [54].