A study of children younger than age 21 years diagnosed with NB or ganglioneuroblastoma between 1990 and 2002 and with known primary site were identified from the International Neuroblastoma Risk Group database has shown that patients with primary adrenal tumors have a statistically significant worse event free survival and overall survival compared to non-adrenal sites (HR 1.17; CI 1.05–1.29) even after adjustment for age, MYCN proto-oncogene status, and stage [20]. The gene discussed is MYCN; the disease is adrenal gland neoplasm.