NFKB1 and Miyoshi myopathy: The interactions of these adhesion molecules result in the upregulation of several intracellular signaling pathways; for example, phosphoinositide 3-kinase (PI3K), signal transducer and activator of transcription 3 (STAT3), nuclear factor-kappa-B (NF-κB) and mitogen-activated protein kinase (MAPK), which leads to the secretion of cytokines (Table 1), activation of osteoclasts, decrease in osteoblasts and increase growth and multiplication of MM cells [20].