FCMR and diffuse large B-cell lymphoma: Since FCMR can have a modulatory effect on BCR signaling pathways [33,44,45], to see whether FCMR expression has any relevance for BCR signaling in ABC-DLBCL, we knocked down FCMR expression in two cell lines (TMD8 and HBL1) with two separate shRNAs (sh62C and sh62D) (Figure 5A).