In contrast, CHOP+AA combinations resulted significantly reduced tumor masses, with mean volumes of 797.1 ± 414.0 mm3 in the single CHOP+AA group and 191.7 ± 126.6 mm3 in the CHOP+AAx5 treatment group (both statistically significant at p ≤ 0.05). This evidence concerns the gene DDIT3 and neoplasm.