Surprisingly, three out of the five most frequent recurrent PVs were associated with substantially higher BC risk (OR > 5) than the overall risk estimated for the entire gene and two other recurrent PVs, which resembles an elevated risk associated with individual variants in other BC risk genes, e.g., the c.7271T>G (V2424G) variant in ATM, c.1036C>T (R346C) in CHEK2, and c.3113G>A (W1038*) in PALB2 [148]. This evidence concerns the gene CHEK2 and breast cancer.