In the asthmatic EMTU, the epithelial release of inflammatory cytokines (CCL-5, IL-1α, TNF-α, IL-8, and IL-6) can regulate mesenchymal inflammation to cause eosinophilia and TH2 inflammation (TSLP, GM-CSF) as well as neutrophilic inflammation (TNF-α, IL-8, IL-6). The gene discussed is CXCL8; the disease is Increased total eosinophil count.