However, increased expression of integrins α5β1 and αvβ3 results in a poor melanoma prognosis, increased cell invasion, and metastasis [61,62], while data obtained in vitro in different melanoma cell lines showed that integrin αvβ5 is involved in the higly aggressive phenotype of cells expressing neuropilin 1 [63], and is involved in sensitivity to microtubule poison paclitaxel and increased in vitro migration and invasion [64,65]. The gene discussed is NRP1; the disease is melanoma.