GRHL2 and neoplasm: Finally, the suggested SKOV3-E hybrid phenotype was supported by the strong expression of the hybrid state–associated phenotypic stability factors (PSFs) OVOL2 and GRHL2 in the SKOV3-E cells, and in tumors derived from SKOV3-E- and SKOV3-E+M-injected animals (Figure 5), while the EMT progression factor Zeb1 was more sustained in SKOV3-M cells and tumor samples from the SKOV3-M-injected mice (Figure 5).