APC2 and ovarian neoplasm: Analysis of primary ovarian tumor samples obtained from our phase 1 experimental animals confirmed these data, as tumor tissues derived from SKOV3-E- and SKOV3-E+M-injected mice displayed considerably diminished β-catenin expression and enhanced Axin1 and APC2, following both Western blot and immunohistochemistry (IHC) analyses, as compared to SKOV3-M-injected mice (Figure 2A,B).