Importantly, SKOV3-E cells, as well as tumor tissues of mice IB-injected with SKOV3-E and SKOV3-E+M cells, displayed enhanced expression of OVOL2 and GRHL2 - two phenotypic stability factors (PSFs), previously shown by us and others to stabilize the highly aggressive and metastatic E/M (hybrid) phenotype of cancer cells [17,38,54,55] (see Figure 5). This evidence concerns the gene OVOL2 and neoplasm.