Indeed, non-tumor cells with mtDNA-deficient mitochondria can resist staurosporine-mediated apoptosis by increased expression of the antiapoptotic proteins BCL-2 and BCL-XL, sequestration of proapoptotic factors (BID, BAX, BAD) in the internal mitochondrial membrane and reduced activation of caspases 3, 8 and 9, among others properties [94]. The gene discussed is BCL2; the disease is neoplasm.