FLI1 and systemic sclerosis: A role for IL-33-producing dermal fibroblasts in Th2-like Treg transdifferentiation has been recently suggested by Saigusa et al. They demonstrated that, in the bleomycin-treated Fli1+/− mice model for SSc, Fli1 haploinsufficiency increased proportions of Th2- and Th17-like Tregs [116].