A profibrogenetic role of IL-33 has been demonstrated for pulmonary fibrosis (idiopathic and SSc-related fibrosis), liver fibrosis (cirrhosis, viral hepatitis, primary biliary cirrhosis, and NASH), pancreatic fibrosis, intestine fibrosis (IBD), renal fibrosis, and skin fibrosis. The gene discussed is IL33; the disease is systemic sclerosis.