Since the inhibition of platelet activation pathways with antiplatelet therapy is crucial for the prevention of atherothrombotic diseases, aspirin (acetylsalicylic acid) has been extensively used as medication in the prevention of cardiovascular events in T2DM patients due to its main ability to suppress thromboxane A2 (TXA2) synthesis, a powerful activator of platelet response and thrombus formation, by irreversibly inhibiting cyclooxygenase-1 (COX-1) activity [4,5]. The gene discussed is PTGS1; the disease is type 2 diabetes mellitus.