When stratified for the absence (HPR-) or the presence of high platelet reactivity (HPR+) based on the response to CEPI PFA-100 (cut-off 193 sec), the percentage of HPR+ in T2DM and HC subjects was similar (23% and 25%, respectively, p = ns) (Figure 1B) and within each group closure time values were significantly different between HPR+ and HPR- (p < 0.0001). Here, HPR is linked to type 2 diabetes mellitus.