A stepwise regression analysis including clinical and laboratory data that differed between HC and T2DM patients and between HPR- and HPR+ within each group (BMI, HbA1c, fasting glucose, TC, HDL-C, LDL-C, SOD, sRAGE, 8-iso-PGF2α, IL-6, sCD40L), entered as independent variables, and CEPI PFA-100 as a dependent variable showed that only SOD significantly predicted platelet reactivity according to CEPI PFA-100 response in both HC (t = 5.941, β = 0.632, p < 0.0001) and T2DM (t = 2.873, β = 0.298, p = 0.005) patients. This evidence concerns the gene IL6 and type 2 diabetes mellitus.