Interestingly, our T2DM patients also showed higher levels of sCD40L and 8-iso-PGF2α and the positive correlation between sCD40L and 11-dhTXB2 and 8-iso-PGF2α (data not shown) confirms that CD40L release occurs during TXA2-dependent activation and is involved in the increased oxidant stress and lipid peroxidation in T2DM [20], respectively. Here, CD40LG is linked to type 2 diabetes mellitus.