TNFRSF1A and carcinoma: Prominent activators of NF-κB signaling are tumor necrosis factor receptor (TNFR) family members, lipopolysaccharides (LPS) and EGFR [40,41], in fact, EGFR and NF-κB are described as co-directional activation signaling pathways in some carcinomas, such as HNCs [42].