NFKB1 and neoplasm: In summary, our study proposes that the activation of the EGFR/PI3K/AKT1/NRF2 pathway by HPV16 E7 leads to PIR/NF-κB activation in tumor oral epithelial cells, resulting in an increased cell migration, with the possibility remaining that this mechanism is involved in other epithelial cell models (Figure 7).