After excluding KEYNOTE-407, we found that the sensitivity analysis of almost all two-treatment comparisons for statistical significance tests delivered unchanged results, although the significant difference in PFS between Niv+Ipi and Pem+PBC in groups with a PD-L1 of 50% or more disappeared, and a significant difference in OS between Niv+Ipi and Niv in a PD-L1 of 50% or more appeared. This evidence concerns the gene CD274 and primary biliary cholangitis.