Since Nrf2 modulates the expression of a large number of genes encoding detoxification enzymes, antioxidant proteins, xenobiotic transporters and other stress response proteins involved in many cellular and molecular pathways, the role of Nrf2-Keap1 signal in ictogenesis (the processes of transition to a seizure) in epilepsy has been elusive. This evidence concerns the gene NFE2L2 and epilepsy.