PIK3CA and ovarian clear cell cancer: Clear-cell ovarian cancers display mutations in the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex genes, the PI3K/Akt signaling pathway, and the receptor tyrosine kinase (RTK)/Ras signaling pathway in nearly 50%, 40%, and 29% of clear-cell ovarian cancers, respectively [10,24,25].