In the case of diabetes mellitus (DM), the ECM components, such as collagen and fibronectin (FN), accumulate in large quantities and the synthesis and expression of profibrotic cytokines increase in GMCs, resulting in the expansion of the mesangial region, mediating the pathological changes in renal fibrosis and eventually leading to end-stage renal disease [3]. Here, FN1 is linked to stage 5 chronic kidney disease.