1,25(OH)2D3 induces up-regulation of E-cadherin and other epithelial marker involved in differentiation such as ZO-1, as well as the inhibition of downstream targets of WNT/β-catenin signaling as c-Myc and cyclin D which results in restraining cancer cell differentiation, a feature which also involved in angiogenesis, migration and invasion. This evidence concerns the gene CDH1 and cancer.