PCSK9 and early-onset autosomal dominant Alzheimer disease: For instance, we detected BRCA1 [31–34] in Breast Cancer (Table 1, Fig 3A, S4 Fig, S3 Table), Amyloid Precursor Protein (APP) in Alzheimer’s Disease [35–37], INS in A1C measurement and Type 2 Diabetes, PCSK9 in LDL cholesterol levels [38,39] and SNCAIP [40,41] in Parkinson’s Disease, and the circadian rhythm gene CRY2 in Morning vs. Evening chronotype [42].