In this study, we developed the JMJD5-overexpressing PDTX model by using cancer cells of a patient with advanced OSCC, and we showed that silibinin downregulates JMJD5 and inhibits cell growth in vitro and in vivo (Figs 4 and 5) and in the PDTX model (Fig 5) of oral cancer. This evidence concerns the gene KDM8 and lip and oral cavity carcinoma.