In this study, we found that JMJD5 was overexpressed in patients with oral cancer and in OSCC cell lines (Fig 1), and it was associated with tumor size, cervical lymph nodes metastasis, clinical stage, and 5-year overall survival rate (Fig 2B), further supporting the role of JMJD5 as a potential prognostic factor in OSCC progression. This evidence concerns the gene KDM8 and lip and oral cavity carcinoma.