MKI67 and breast cancer: In a recently published validation study, authors reported the prognostic stage provides more accurate prognostic information than does the anatomic stage alone, thus supporting the use of prognostic stage in breast cancer staging.38 In the current study, cancer in the majority of patients (82.3%) was detected at an early prognostic stage (0-I), and patients with interval cancers were more likely to have a worse prognostic stage (OR, 3.59; 95% CI, 0.9 to 14.5) with high Ki-67 scores (OR, 3.14; 95% CI, 0.9 to 11.2) compared with screen-detected cancers.