In logistic regression analysis, interval cancers were associated with more-advanced prognostic stages (prognostic stage II-IV v stage 0 and I; OR, 3.59; 95% CI, 0.9 to 14.5) and high Ki-67 positivity (Ki-67 ≥ 20% v < 20; OR, 3.14; 95% CI, 0.9 to 11.2) compared with patients with screen-detected cancers. This evidence concerns the gene MKI67 and cancer.