AR and esophageal squamous cell carcinoma: As ESCC tissues hardly expresses AR (Figure 7D), thus, it is reasonable to infer that the metabolites 3α‐diol may be reused to biosynthesis PI, known as a precursor of PI3K,52 following by activating the PI3K/AKT pathway in an AR‐independent manner,43, 44, 45, 46 However, there is insufficient evidence that whether 3α‐diol could biosynthesis PI directory in vivo.