The present studies showed the influences of SREBP1c on both receptors for TGFβ1 and PDGFβ, the most important cytokines for inducing HSC activation and liver fibrosis,16 and on their downstream signalling pathways of Smad3 and Akt1/2/3 in HSCs. This evidence concerns the gene TGFB1 and Hepatic fibrosis.