Five proteins altered by HF diet from the proteomic dataset were selected (paraspeckle component 1 [PSPC-1], sterol regulatory element-binding protein 2 [SREBP2], filamin A [FLNA], apolipoprotein A1 [APOA1] spermatogenesis associated 20 [SPATA-20]) (Supplementary Table 4). The gene discussed is SPATA20; the disease is hydrops fetalis.