For example, CCL2 causes upregulation of MCP-1-induced protein (MCPIP) in cardiomyocytes in a mouse model of heart failure.57 MCPIP induces cardiomyocyte apoptosis by causing ROS accumulation and endoplasmic reticulum stress in cardiomyocytes.57 Osteoclasts participate in inflammation-induced bone resorption. This evidence concerns the gene CCL2 and heart failure.