NFKB1 and periodontitis: In addition, proinflammatory cytokines have been reported to aggravate periodontitis by inducing NF-κB activation in osteoblasts, a process that plays an important role in bone resorption.53 We deduced that bindarit may reduce NF-κB activation in osteoblasts by suppressing periodontal inflammation, thereby reducing alveolar bone loss.