After further analyzed by GSEA, we found the Epithelial Mesenchymal Transition gene set was the top one enriched in samples with hypomethylation on P1 CpG sites of Zac1 promoter (Fig. 5C, D), similar results were observed in another clinical cervical carcinoma database GSE68339 (Supplement Fig. 1 in Supplementary information 3). This evidence concerns the gene PLAGL1 and cervical carcinoma.