To investigate the correlation between Zac1 mRNA expression and methylation status of various CpG sites on Zac1 promoter, TCGA-CESC and GSE68339 cervical carcinoma databases were utilized for detailed analysis, in which Zac1 expression as well as the methylation status of its promoter could be obtained at the same time. The gene discussed is PLAGL1; the disease is cervical carcinoma.