In particular, ALS-linked mutations have been reported in DCTN1 (dynein-associated polypeptide)16, PFN1 (profilin, an actin cytoskeleton regulator)17, TUBA4A (tubulin 4A)18 and the annexin family member ANXA1119. This evidence concerns the gene TUBA4A and amyotrophic lateral sclerosis.