This also suggests the large majority of ESCC cells with GSK3β inhibition in the G2/M phase undergo apoptosis and only cells that survive enter the next round of cell cycle, which is reflected by decreased EdU labeling by GSK3β inhibition (Fig. 2B, Supplementary Figs. S5, S6). The gene discussed is GSK3B; the disease is esophageal squamous cell carcinoma.